Brian Barneclo was born and raised in Indianapolis, then studied painting and art history at Indiana University. He moved to San Francisco in 1996 and began working as a commercial artist and sign painter. He also started to show his paintings in local galleries. His professional and artistic careers merged when he began to receive commissions for murals in both public and private spaces.

Barneclo has adorned the walls of many Bay Area's restaurants and streets with his jazzy colorful murals inspired by life in San Francisco -- NoPa Restaurant, Puccini & Pinetti, 83 McAllister Street, the SF Bay Guardian building, the Food Chain Mural @ Foods Co, Escape from New York Pizza (Redwood City), and the Santa Cruz Mural (Santa Cruz). He was named one of San Francisco's top muralists by 7x7 Magazine in 2008.